Dr Stephen Jenkins
Location: Room 304, Ashworth Laboratories
Phone: 0131 650 7317
Email: stephen.jenkins@ed.ac.uk
Website: http://www.nematodes.org/allenlab/people/jenkins.htm
CV
- 2007-current: Postdoctoral Fellow in the Allen Lab, Institute of Immunology and Infection Research (3IR), University of Edinburgh
- 2003-2007: Post-Doctoral Research Fellow, Laboratory of Dr. A. MacDonald, IIIR, University of Edinburgh: The role of co-stimulation in development of polarised T-helper responses induced by pathogen-exposed dendritic cells and during murine schistosomiasis.
- 2002-2003: Research Technician, Laboratory of Dr. A. Mountford, Dept. of Biology, University of York: Proteomic analysis of activated dendritic cells.
- 1999-2003: PhD, Laboratory of Dr. A. Mountford, Dept. of Biology, University of York: Analysis of the interaction between the parasite and innate accessory cells, focusing upon the subsequent generation of adaptive immune responses via the polarisation of the T-helper cell population.
- 1999: Voluntary Research Assistant, Laboratory of Prof. R. Grencis, Dept. of Immunology, University of Manchester: Investigation of concomitant malaria and Trichinella infection in the mouse model; analysis of the kinetics of infection, and the intestinal mastocytosis associated with trichinosis.
- 1995 - 1998: BSc Biology (2i Hon.), Dept. of Biology, University of Manchester.
Awards
* Team Finalist in the National ‘Biotechnology Young Entrepreneurs Scheme’ 2001, and Winner of the award for ‘Best Global Strategy’,.
* Winner of the ‘Graduate Research Presentation Prize’, British Society for Parasitology Annual Conference, 2001.
Publications
- Jenkins SJ, Rückerl D, Cook PC, Jones LH, Finkelman FD, van Rooijen N, MacDonald AS and Allen JE. (2011).
- Local macrophage proliferation, rather than recruitment from the blood, is a signature of Th2 inflammation. Science. Published on-line May 12. Supplementary on-line material.
- Stephen J. Jenkins and Judith E. Allen. (2010).
- Similarity and Diversity in Macrophage Activation by Nematodes, Trematodes, and Cestodes. Journal of Biomedicine and Biotechnology. Vol. 2010 (2010), Article ID 262609.
- Stephen J. Jenkins, Georgia Perona-Wright, Alan G.F. Worsley, Naoto Ishii and Andrew S. MacDonald. (2007).
- Dendritic cell expression of OX40L acts as a costimulatory, not polarizing, signal for optimal Th2 priming and memory induction in vivo. Journal of Immunology .179(6):3515-23 .
- Georgia Perona-Wright, Stephen J. Jenkins, Alison Crawford, David Gray, Edward J. Pearce and Andrew S. MacDonald. (2006).
- Distinct sources and targets of IL-10 during dendritic cell-driven Th1 and Th2 responses in vivo. European Journal of Immunology. 36(9): 2367-2375.
- Georgia Perona-Wright, Stephen J. Jenkins, and Andrew S. MacDonald. (2006).
- Dendritic cell activation and function in response to Schistosoma mansoni. International Journal for Parasitology. 36(6): 711-721.
- Jenkins, S.J., Hewitson, J.P., Ferret-Bernard, S. and Mountford, A.P. (2005).
- Schistosome larvae stimulate macrophage cytokine production through TLR4-dependent and independent pathways. International Immunology. 17 (11):1409-18.
- Jenkins, S.J., Hewitson, J.P., Jenkins, G.R. and Mountford, A.P. (2005).
- Modulation of the host’s response by schistosome larvae. Parasite Immunology. 27: 385-393.
- Jenkins, S.J., and Mountford, A.P. (2005).
- Dendritic cells activated with products released by schistosome larvae drive Th2-type immune responses, which can be inhibited by manipulation of CD40 costimulation. Infection and Immunity. 73:395-402.
- Mountford, A.P. & Jenkins, S.J. (2004).
- Vaccine development: Lessons from the study of initial immune responses to invading larvae. Chapter 5. In World Class Parasites (Vol. 9): Schistosomiasis. Eds E. Secor and D.G. Colley. Kluwer Academic Publishers.