Recent Publications

2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | Older

2008

Allen, JE, O Adjei, O Bain, A Hoerauf, W Hoffmann, B Makepeace, H Schulz-key, AJ Trees, S Wanji & DW Taylor.  
Of mice cattle and humans: the immunology and treatment of river blindness. PLOS NTD. In press.
Houston, KM, SA Babayan, JE Allen, W Harnett.   
Does Litomosoides synthesise dimethylethanoloamine from choline? Parasitology. 135:55-61.
Lamb, TJ, A Harris, L Le Goff, AF Read & JE Allen.  
Litomosoides sigmodonits: Vaccine-induced immune responses against Wolbachia surface protein can enhance the survival of filarial nematodes during primary infection. Experimental Parasitology. 118:285-289.
Long GH, Chan BH, Allen JE, Read AF, Graham AL .
Blockade of the TNF receptor 1 reduces disease severity but increases parasite trasmission during Plasmodium chabaudi chabaudi infection. International Journal of Parasitology. In press.
 
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2007

Diaz, A & JE Allen
Mapping immune response profiles: the emerging scenario from helminth immunology. European Journal of Immunology. 37:3319-26.
Loke, P, I Gallagher, MG Nair, X Zang, F Brombacher, M Mohrs, JP Allison & JE Allen.   
Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection. Journal of Immunology. 179: 3926-36.
Taylor, MD, A Harris, S Babayan, O Bain, JE Allen & RM Maizels .   
CTLA-4 and CD4+CD25+ regulatory T cells synergize to inhibit protective immunity to filarial parasites in vivo. Journal of Immunology. 179: 4626-34
 
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2006

Taylor, MD, A Harris, MG Nair, RM Maizels & JE Allen .   
F4/80+ alternatively activated macrophages control CD4+ T cell hyporesponsiveness at sites peripheral to filarial infection. Journal of Immunology 176:6918-6927.
Arora, M. , L. Chen, M Paglia, I Gallagher, JE Allen, YM Vyas, A Ray & P Ray   
Simvastatin promotes Th2-type responses through induction of the chitinase family member Ym1 in dendritic cells.Proc Natl Acad Sci USA. 103:7777-7782.
Babayan, SA, T Attout, A Harris, MD Taylor, L Le Goff, PN Vuong, L Renia, JE Allen, O Bain   
Vaccination against filarial nematodes with irradiated larvae provides long-term protection against the third larval stage but not against subsequent life cycle stages. International Journal of Parasitology. 36(8):903-14.
Long GH, Chan BH, Allen JE, Read AF, Graham A  
Parasite genetic diversity does not influence TNF-mediated effects on the virulence of primary rodent malaria infections. Parasitology. 133(Pt 6):673-84
 
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2005

Loke, P, Xx Zang, L Hsuan, R Waitz, RM Locksely,   JE Allen and JP Allison. 2005.   
ICOS is not required for Th2 response during chronic nematode infection, but is required for type 2 antibody switching. Proc Natl Acad Sci USA. 102:9872-7
Lamb, TJ., AL Graham, L Le Goff, & JE Allen.   2005
Co-infected C57BL/6 mice mount appropriately polarized and compartmentalized cytokines responses to Litomosoides sigmodontis and Leishmania major but disease progression is altered. Parasite Immunology. 27:317-24
Graham, AL., JE Allen, & AF Read. 2005c.
Evolutionary causes and consequences of immunopathology. Annual Review of Ecology, Evolution, and Systematics.vol 36: 373-398
Graham, AL, MD Taylor, L Le Goff, TJ Lamb, M Magennis & JE Allen. 2005b.
Quantitative appraisal of murine filariasis reveals greater susceptibility to Litomosoides sigmodontis among female hosts across all parasite life cycle stages. Microbes and Infection. 7:612-618.
Taylor, MD, L LeGoff, A Harris, E Malone, M Nair, JE Allen, and RM Maizels. 2005.
Regulatory T cell activity inhibits protective immune responses in vivo and is the major determinate of susceptibility to filarial infection Journal of Immunology. 174: 4924-4933.
Nair, MG, IJ Gallagher, MD Taylor, P Loke, PS Coulson, RA Wilson, RM Maizels & JE Allen. 2005.
Chitinases and Fizz family members (CHAFF) are a generalized response to nematode infection with selective upregulation of Ym1 and Fizz1 by antigen presenting cells. Infection and Immunity 73(1):385-94. [see Faculty of 1000 evaluation]
Graham, AL, TJ Lamb, AF Read, & JE Allen. 2005.
Malaria-filaria co-infection in mice leads to increases in malarial parasitemia and virulence unless filarial infection achieves patency. Journal of Infectious Disease. 191:410-421
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2004

Lamb, TJ, L Le Goff, A Kurniawan, DB Guiliano, K Fenn, ML Blaxter, AF Read & JE Allen. 2004.
The Majority of the Response Elicited Against Wolbachia Surface Protein in Filarial Nematode Infection is Due to the Infective Larval Stage. Journal of Infectious Disease. 189:120-7. [see Faculty of 1000 evaluation]
Tawill, S, L LeGoff, F Ali, ML Blaxter & JE Allen. 2004.
Both free-living and parasitic nematodes induce a characteristic Th2 response that is dependent on the presence of intact glycans. Infection and Immunity. 72:398-407.
Heasman, SJ Katherince M Giles, AG Rossi, JE Allen, C Haslett & I Dransfield. 2004.
Interferon g suppresses glucocorticoid augmentation of macrophage clearance of apoptotic cells. European Journal of Immunology. 34:1752-61.
Maizels, RM, A Balic, N Gomez-Escobar, MG Nair, MD Taylor & JE Allen. 2004.
Helminth Parasites: Masters of Regulation. Immunological Reviews. 201: 89-116.
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2003

Nair, MG, DW Cochrane & JE Allen. 2003.
Macrophages in chronic type 2 inflammation have a distinctive phenotype that is partly replicated by in vitro treatment with type 2 cytokines. Immunology Letters. 85: 173-180.
MacDonald, AS, P Loke, I Dransfield & JE Allen. 2003.
Cytokine-dependent inflammatory cell recruitment patterns in the peritoneal cavity of mice exposed to the parasitic nematode Brugia malayi. Medical Microbiology and Immunology 192:33-40
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2002

Lundén, A S Wright, JE Allen & D Buxton. 2002.
Immunisation of mice against neosporosis. International Journal of Parasitology. 32: 867-876.
Garofalo, A, SL Kläger, MC Rowlinson, N Nirmalan, A Klion, JE Allen, MW Kennedy, JE Bradley. 2002.
The FAR proteins of filarial nematodes: secretion, glycosylation and lipid binding characteristics. Molecular and Biochemical Parasitology 122: 161-170.
Loke, P, MG Nair, J Parkinson, D Guiliano, ML Blaxter & JE Allen. 2002.
IL-4 dependent alternatively activated macrophages have a distinctive in vivo gene expression phenotype. BMC Immunology. 3:7
Le Goff, L. TJ Lamb, AL Graham, Y Harcus & JE Allen. 2002.
IL-4 is required to prevent filarial nematode development in resistant but not susceptible strains of mice. International Journal of Parasitology. 32: 1277-1284.
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2001

Falcone, FH, P Loke (joint first author), Xx Zang, AS MacDonald, RM Maizels & JE Allen. 2001.
A Brugia malayi homologue of macrophage migration inhibitory factor reveals an important link between macrophages and eosinophil recruitment during nematode infection. Journal of Immunology 167: 5348-55
Allen, JE & P’ng Loke. 2001.
Divergent Roles for Macrophages in Lymphatic Filariasis. Parasite Immunology. 23:345-352
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2000

Lawrence, RA, JE Allen, & CA Gray. 2000.
Requirements for IFN-g induction by microfilariae of the parasitic nematode, Brugia malayi. Parasitology. 120: 631-640.
Loke, P, AS MacDonald, and Judith E. Allen. 2000a.
Antigen presenting cells recruited by Brugia malayi drive Th2 differentiation of naïve CD4+ T cells. European Journal of Immunology. 30:1127-1135.
LeGoff, L. P’ng Loke, F Ali, DW Taylor and Judith E. Allen. 2000.
IL-5 is essential for vaccine mediated immunity but not innate resistance to a filarial parasite. Infection and immunity.68:2513-1517.
Gregory, WF, AK Atmadja, JE Allen & RM Maizels. 2000.
The abundant larval transcript-1/2 genes of Brugia malayi encode stage-specific candidate vaccine antigens for filariasis. Infection and Immunity. 68: 4174-4179.
Allen, JE, J Daub, D Guiliano, A O’Connell, M Lizotee-Waniewski, DW Taylor and Mark Blaxter. 2000.
Analysis of genes expressed at the infective larval stage validates utility of Litomosoides sigmodontis as a murine model for filarial vaccine development. Infection and Immunity. 68: 5454-5458.
Loke, P, AS MacDonald, A Robb, RM Maizels & JE Allen. 2000b.
Alternatively activated macrophages recruited by Brugia malayi suppress proliferation via a contact dependent mechanism. European Journal of Immunology. 30: 2669-2678.
Read AF & JE Allen. 2000.
Perspective: The Economics of Immunity. Science. 290:1104-1105
Zang, X., AK Atmadja, P Gray, JE Allen, CE Gray, RA Lawrence, M Yazdanbakhsh, & RM Maizels 2000.
The serpin secreted by Brugia malayi microfilariae, Bm-SPN-2, elicits strong but short-lived immune responses in mice and humans. Journal of Immunology. 165: 5161-5169
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Older Publications of continuing interest:

Nirmalan, N. Nuno Cordiero, Sabine L. Klager, Janet E. Bradley and Judith E. Allen. 1999.
Comparative analysis of glycosylated and non-glycosylated filarial homologues of the 20KDa retinol binding protein from Onchocerca volvulus. Infection and Immunity. 67: 6329-34
Allen, JE and AS MacDonald. 1998.
Profound suppression of cellular proliferation mediated by the secretions of nematodes. Parasite Immunology. 20:241-247.
MacDonald, AS, RM Maizels, RA Lawrence, I Dransfield and JE. Allen. 1998.
Requirement for the in vivo production of IL-4, but not IL-10, in induction of proliferative suppression by filarial parasites. Journal of Immunology. 160:4124-4132
Allen, JE and RM Maizels. 1997.
Th1/Th2 - Reliable Paradigm or Dangerous Dogma? Immunology Today. 18:387-392.
Allen, JE, RA Lawrence and RM Maizels. 1996.
Antigen presenting cells from mice harboring the filarial nematode, Brugia malayi, prevent cellular proliferation but not cytokine production. International Immunology. 8:143-151.
Allen, JE, RA Lawrence and RM Maizels. 1995.
Fine specificity of the genetically controlled immune response to native and recombinant gp15/400 (polyprotein allergen) of Brugia malayi. Infection and Immunity. 63: 2892-2898
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