Recent Publications

2010 | 2009 |2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | Older

 

2010

Stephen J. Jenkins and Judith E. Allen.
Similarity and Diversity in Macrophage Activation by Nematodes, Trematodes, and Cestodes. Journal of Biomedicine and Biotechnology. Vol. 2010 (2010), Article ID 262609.
 
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2009

Prieto-Lafuente, L, WF Gregory, JE Allen and RM Maizels.
MIF Homologues from Filarial nematode parasites selectively activated macrophages synergising with IL-4 to induce alternative activation. Journal of Leukocyte Biology. 2009 Jan 29. 85(5):844-54.
Mylonas, KJ, MG Nair, L Prieto-Lafuente, D Paape and JE Allen.
Alternatively activated macrophages elicited by helminth infection can be reprogrammed to enable microbial killing. Journal of Immunology. 2009 Mar 1;182(5):3084-94.
Sutherland, T, RM Maizels & JE Allen.
Chitinases in allergic Inflammation. Clincal & Experimental Allergy. 39:943-55.
Marieke A Hoeve, Katie J Mylonas, Karen J Fairlie-Clarke, Simmi M Mahajan, Judith E Allen and Andrea L Graham.
Plasmodium chabaudi limits early Nippostrongylus brasiliensis-induced pulmonary immune activation and Th2 polarization in co-infected mice. BMC Immunol (2009) vol. 10 pp. 60.
 
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2008

Taylor, MD, N van der Werf, A Harris, AL Graham, O Bain, JE Allen, and RM Maizels.
Early recruitment of natural CD4+Foxp3+ regulatory T cells by infective larvae determines the outcome of filarial infection. European Journal of Immunology. 2009 Jan;39(1):192-206.
Gangadharan, B, MA Hoeve (joint first author), JE Allen, B Ebrahimi, SM Rhind, BM Dutia & AA Nash.
Gammaherpesvirus induced splenic fibrosis: the role of alternatively activated macrophages. Journal of Leukocyte Biology. 84:50-8
Allen, JE, O Adjei, O Bain, A Hoerauf, W Hoffmann, B Makepeace, H Schulz-key, AJ Trees, S Wanji & DW Taylor.  
Of mice cattle and humans: the immunology and treatment of river blindness. PLOS NTD. 2(4):e217.
Houston, KM, SA Babayan, JE Allen, W Harnett.   
Does Litomosoides synthesise dimethylethanoloamine from choline? Parasitology. 135:55-61.
Lamb, TJ, A Harris, L Le Goff, AF Read & JE Allen.  
Litomosoides sigmodonits: Vaccine-induced immune responses against Wolbachia surface protein can enhance the survival of filarial nematodes during primary infection. Experimental Parasitology. 118:285-289.
Long GH, Chan, BHK, JE Allen, AF Read and AL Graham.  
Experimental manipulation of immune-mediated disease and its fitness costs for rodent malaria parasites. BMC Evolutionary Biology. 8: 128
Long GH, Chan BH, Allen JE, Read AF, Graham AL.   
Blockade of the TNF receptor 1 reduces disease severity but increases parasite trasmission during Plasmodium chabaudi chabaudi infection. International Journal of Parasitology. 38:1073-81.
 
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2007

Diaz, A & JE Allen
Mapping immune response profiles: the emerging scenario from helminth immunology. European Journal of Immunology. 37:3319-26.
Loke, P, I Gallagher, MG Nair, X Zang, F Brombacher, M Mohrs, JP Allison & JE Allen.   
Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection. Journal of Immunology. 179: 3926-36.
Taylor, MD, A Harris, S Babayan, O Bain, JE Allen & RM Maizels .   
CTLA-4 and CD4+CD25+ regulatory T cells synergize to inhibit protective immunity to filarial parasites in vivo. Journal of Immunology. 179: 4626-34
 
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2006

Taylor, MD, A Harris, MG Nair, RM Maizels & JE Allen .   
F4/80+ alternatively activated macrophages control CD4+ T cell hyporesponsiveness at sites peripheral to filarial infection. Journal of Immunology 176:6918-6927.
Arora, M. , L. Chen, M Paglia, I Gallagher, JE Allen, YM Vyas, A Ray & P Ray   
Simvastatin promotes Th2-type responses through induction of the chitinase family member Ym1 in dendritic cells.Proc Natl Acad Sci USA. 103:7777-7782.
Babayan, SA, T Attout, A Harris, MD Taylor, L Le Goff, PN Vuong, L Renia, JE Allen, O Bain   
Vaccination against filarial nematodes with irradiated larvae provides long-term protection against the third larval stage but not against subsequent life cycle stages. International Journal of Parasitology. 36(8):903-14.
Long GH, Chan BH, Allen JE, Read AF, Graham A  
Parasite genetic diversity does not influence TNF-mediated effects on the virulence of primary rodent malaria infections. Parasitology. 133(Pt 6):673-84
 
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2005

Loke, P, Xx Zang, L Hsuan, R Waitz, RM Locksely,   JE Allen and JP Allison. 2005.   
ICOS is not required for Th2 response during chronic nematode infection, but is required for type 2 antibody switching. Proc Natl Acad Sci USA. 102:9872-7
Lamb, TJ., AL Graham, L Le Goff, & JE Allen.   2005
Co-infected C57BL/6 mice mount appropriately polarized and compartmentalized cytokines responses to Litomosoides sigmodontis and Leishmania major but disease progression is altered. Parasite Immunology. 27:317-24
Graham, AL., JE Allen, & AF Read. 2005c.
Evolutionary causes and consequences of immunopathology. Annual Review of Ecology, Evolution, and Systematics.vol 36: 373-398
Graham, AL, MD Taylor, L Le Goff, TJ Lamb, M Magennis & JE Allen. 2005b.
Quantitative appraisal of murine filariasis reveals greater susceptibility to Litomosoides sigmodontis among female hosts across all parasite life cycle stages. Microbes and Infection. 7:612-618.
Taylor, MD, L LeGoff, A Harris, E Malone, M Nair, JE Allen, and RM Maizels. 2005.
Regulatory T cell activity inhibits protective immune responses in vivo and is the major determinate of susceptibility to filarial infection Journal of Immunology. 174: 4924-4933.
Nair, MG, IJ Gallagher, MD Taylor, P Loke, PS Coulson, RA Wilson, RM Maizels & JE Allen. 2005.
Chitinases and Fizz family members (CHAFF) are a generalized response to nematode infection with selective upregulation of Ym1 and Fizz1 by antigen presenting cells. Infection and Immunity 73(1):385-94. [see Faculty of 1000 evaluation]
Graham, AL, TJ Lamb, AF Read, & JE Allen. 2005.
Malaria-filaria co-infection in mice leads to increases in malarial parasitemia and virulence unless filarial infection achieves patency. Journal of Infectious Disease. 191:410-421
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2004

Lamb, TJ, L Le Goff, A Kurniawan, DB Guiliano, K Fenn, ML Blaxter, AF Read & JE Allen. 2004.
The Majority of the Response Elicited Against Wolbachia Surface Protein in Filarial Nematode Infection is Due to the Infective Larval Stage. Journal of Infectious Disease. 189:120-7. [see Faculty of 1000 evaluation]
Tawill, S, L LeGoff, F Ali, ML Blaxter & JE Allen. 2004.
Both free-living and parasitic nematodes induce a characteristic Th2 response that is dependent on the presence of intact glycans. Infection and Immunity. 72:398-407.
Heasman, SJ Katherince M Giles, AG Rossi, JE Allen, C Haslett & I Dransfield. 2004.
Interferon g suppresses glucocorticoid augmentation of macrophage clearance of apoptotic cells. European Journal of Immunology. 34:1752-61.
Maizels, RM, A Balic, N Gomez-Escobar, MG Nair, MD Taylor & JE Allen. 2004.
Helminth Parasites: Masters of Regulation. Immunological Reviews. 201: 89-116.
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2003

Nair, MG, DW Cochrane & JE Allen. 2003.
Macrophages in chronic type 2 inflammation have a distinctive phenotype that is partly replicated by in vitro treatment with type 2 cytokines. Immunology Letters. 85: 173-180.
MacDonald, AS, P Loke, I Dransfield & JE Allen. 2003.
Cytokine-dependent inflammatory cell recruitment patterns in the peritoneal cavity of mice exposed to the parasitic nematode Brugia malayi. Medical Microbiology and Immunology 192:33-40
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2002

Lundén, A S Wright, JE Allen & D Buxton. 2002.
Immunisation of mice against neosporosis. International Journal of Parasitology. 32: 867-876.
Garofalo, A, SL Kläger, MC Rowlinson, N Nirmalan, A Klion, JE Allen, MW Kennedy, JE Bradley. 2002.
The FAR proteins of filarial nematodes: secretion, glycosylation and lipid binding characteristics. Molecular and Biochemical Parasitology 122: 161-170.
Loke, P, MG Nair, J Parkinson, D Guiliano, ML Blaxter & JE Allen. 2002.
IL-4 dependent alternatively activated macrophages have a distinctive in vivo gene expression phenotype. BMC Immunology. 3:7
Le Goff, L. TJ Lamb, AL Graham, Y Harcus & JE Allen. 2002.
IL-4 is required to prevent filarial nematode development in resistant but not susceptible strains of mice. International Journal of Parasitology. 32: 1277-1284.
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2001

Falcone, FH, P Loke (joint first author), Xx Zang, AS MacDonald, RM Maizels & JE Allen. 2001.
A Brugia malayi homologue of macrophage migration inhibitory factor reveals an important link between macrophages and eosinophil recruitment during nematode infection. Journal of Immunology 167: 5348-55
Allen, JE & P’ng Loke. 2001.
Divergent Roles for Macrophages in Lymphatic Filariasis. Parasite Immunology. 23:345-352
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2000

Lawrence, RA, JE Allen, & CA Gray. 2000.
Requirements for IFN-g induction by microfilariae of the parasitic nematode, Brugia malayi. Parasitology. 120: 631-640.
Loke, P, AS MacDonald, and Judith E. Allen. 2000a.
Antigen presenting cells recruited by Brugia malayi drive Th2 differentiation of naïve CD4+ T cells. European Journal of Immunology. 30:1127-1135.
LeGoff, L. P’ng Loke, F Ali, DW Taylor and Judith E. Allen. 2000.
IL-5 is essential for vaccine mediated immunity but not innate resistance to a filarial parasite. Infection and immunity.68:2513-1517.
Gregory, WF, AK Atmadja, JE Allen & RM Maizels. 2000.
The abundant larval transcript-1/2 genes of Brugia malayi encode stage-specific candidate vaccine antigens for filariasis. Infection and Immunity. 68: 4174-4179.
Allen, JE, J Daub, D Guiliano, A O’Connell, M Lizotee-Waniewski, DW Taylor and Mark Blaxter. 2000.
Analysis of genes expressed at the infective larval stage validates utility of Litomosoides sigmodontis as a murine model for filarial vaccine development. Infection and Immunity. 68: 5454-5458.
Loke, P, AS MacDonald, A Robb, RM Maizels & JE Allen. 2000b.
Alternatively activated macrophages recruited by Brugia malayi suppress proliferation via a contact dependent mechanism. European Journal of Immunology. 30: 2669-2678.
Read AF & JE Allen. 2000.
Perspective: The Economics of Immunity. Science. 290:1104-1105
Zang, X., AK Atmadja, P Gray, JE Allen, CE Gray, RA Lawrence, M Yazdanbakhsh, & RM Maizels 2000.
The serpin secreted by Brugia malayi microfilariae, Bm-SPN-2, elicits strong but short-lived immune responses in mice and humans. Journal of Immunology. 165: 5161-5169
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Older Publications of continuing interest:

Nirmalan, N. Nuno Cordiero, Sabine L. Klager, Janet E. Bradley and Judith E. Allen. 1999.
Comparative analysis of glycosylated and non-glycosylated filarial homologues of the 20KDa retinol binding protein from Onchocerca volvulus. Infection and Immunity. 67: 6329-34
Allen, JE and AS MacDonald. 1998.
Profound suppression of cellular proliferation mediated by the secretions of nematodes. Parasite Immunology. 20:241-247.
MacDonald, AS, RM Maizels, RA Lawrence, I Dransfield and JE. Allen. 1998.
Requirement for the in vivo production of IL-4, but not IL-10, in induction of proliferative suppression by filarial parasites. Journal of Immunology. 160:4124-4132
Allen, JE and RM Maizels. 1997.
Th1/Th2 - Reliable Paradigm or Dangerous Dogma? Immunology Today. 18:387-392.
Allen, JE, RA Lawrence and RM Maizels. 1996.
Antigen presenting cells from mice harboring the filarial nematode, Brugia malayi, prevent cellular proliferation but not cytokine production. International Immunology. 8:143-151.
Allen, JE, RA Lawrence and RM Maizels. 1995.
Fine specificity of the genetically controlled immune response to native and recombinant gp15/400 (polyprotein allergen) of Brugia malayi. Infection and Immunity. 63: 2892-2898
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