The Filarial Genome Project

The Filarial Genome Project (FGP) is a multinational initiative to

* identify new drug targets in human parasitic filarial nematodes through EST sequencing
* identify new vaccine candidates in human parasitic filarial nematodes through EST sequencing
* map and sequence the genome of the filariasis nematode Brugia malayi

General Information * Filarial Biology and Pathology * The Filarial Genome Project *

Genome Information * Brugia EST sequencing * Other filarial ESTs * * Brugia malayi Genome Sequencing at TIGR * * Brugia malayi genome sequence from Edinburgh/Sanger Institute * * Wolbachia genome sequencing of Brugia and Onchocerca *

see below for more details....

	what	why	who/curator
	FilGenNet	The FGP www site including summaries of findings, methods, resources and contacts	Mark Blaxter
	Filarial Biology and Pathology	An introduction to the biology of filaria and the diseases they cause	Mark Blaxter
	Filarial nematode EST datasets	The NEMBASE database includes EST information on several filarial nematodes. NEMBASE is a postgreSQL based database for the display and analysis of "fragmented" or "partial" genome sequence, such as that produced in EST or GSS projects	Mark Blaxter
	Filarial gene Nomenclature	We host the FUNK gene nomenclature database for B. malayi	Mark Blaxter
	Brugia malayi Genome mapping	Using gridded BAC libraries, we are generating genome maps for Brugia malayi	Mark Blaxter
	Brugia malayi Genome Sequencing at TIGR	TIGR has been funded by the US NIAID to perform an eight-fold coverage shotgun sequence survey of the Brugia malayi genome.	For B. malayi Comments/Questions send mail to bmalayi@tigr.org
	Brugia malayi Genome Survey Sequencing (GSS)	In collaboration with the Sanger Institute we are generating GSS data for B. malayi	Claire Whitton and Mark Blaxter
	Brugia malayi genome sequence from Edinburgh and the Sanger Institute	In collaboration with the Sanger Institute we are sequncing selected B. malayi BAC clones that cover genes-of-interest.	Mark Blaxter
	The Brugia malayi mitochondrial genome	We have sequenced the 13 kb mitochondrial genome of B. malayi	Mark Blaxter
	The Wolbachia endosymbionts of Brugia malayi and Onchocerca volvulus	Filarial nematodes live in symbiosis with a bacterial partner, closely related to the Wolbachia parasites of arthropods. We are in collaboration with the Sanger Institute, NEB and TIGR, sequencing and analysing the genomes of two nematode symbionts	Katelyn Fenn and Mark Blaxter