Clade I

Clade I nematodes are in the main freeliving, marine animals. Two parasitic orders are placed in Clade I however: the insect-parasitic Mermithidae, and the animal parasitic Trichinellidae (also known as Trichocephalidae).

Trichinellidae

database

description

EST effort

Trichinella spiralis

http://www.nematode.net/

a preliminary analysis of the first ESTs is available here

Trichinella spiralis is a fascinating parasite of vertebrate skeletal muscle. In the wild it is found in many species, but particularly top carnivores. It is an important zoonosis of humans.

A small number of ESTs have been sequenced in Edinburgh in collaboration with Murray Selkirk (London, libraries) and Bernadette Connoly (Aberdeen, libraries). Additional ESTs are being sequenced at Washington university St. Louis.

Trichuris trichiura

NEMBASE

T. trichiura is the whipworm of humans which infects hundreds of millions of people worldwide.

ESTs are being sequenced in Edinburgh in collaboration with the Pathogen Sequencing Unit at the Sanger Institute.

Trichuris muris

NEMBASE

T. muris is a rodent model for the human whipworm parasite

ESTs are being analysed in Edinburgh in collaboration with Richard Grencis (Manchester, libraries) and the Pathogen Sequencing Unit at the Sanger Institute.

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