Clade III

All known species in Clade III are parasites of animals. The clade includes the orders Ascaridida, Oxyurida, Rhigonematida and Spirurida.

Ascaridida

database

description

EST effort

Ascaris suum

NEMBASE

a preliminary analysis of the first EST data is available here

A. suum is a gut parasite of pigs, often used as a model for human ascariasis, but an important veterinary pathogen in its own right.

ESTs are being sequenced in Edinburgh in collaboration with Malcolm Kennedy (Glasgow; libraries), Al Scott (Baltimore, USA; libraries), Tim Geary (Kalamazoo, USA; libraries) and the Pathogen Sequencing Unit at the Sanger Institute. Additional ESTs are being sequenced at Washington university St. Louis.

Ascaris lumbricoides

NEMBASE

A. lumbricoides is the causative agent of human ascariasis, which infects over a billion people worldwide, causing significant morbidity and mortality

ESTs are being sequenced in Edinburgh in collaboration with the Pathogen Sequencing Unit at the Sanger Institute.

Toxocara canis

NEMBASE

T. canis is a canine parasite that can cause serious zoonotic infections of humans.

ESTs are being analysed in Edinburgh in collaboration with Rick Maizels (Edinburgh).

Spirurida

Brugia malayi

NEMBASE

Brugia specific search page

W. bancrofti is a human lymphatic filarial parasite, causing elephantiases and other syndromes. See the FGP home pages for information.

The B. malayi ESTs were generated by an international consortium of labs including Edinburgh. See the FGP home pages for information.

Wuchereria bancrofti

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W. bancrofti is the major human lymphatic filarial parasite, causing elephantiases and other syndromes. See the FGP home pages for information.

The W. bancrofti EST program was carried out by Steve Williams (MA, USA).

Onchocerca volvulus

NEMBASE

O. volvulus is a cutaneous parasite of humans, causing river blindness and skin disease. See the FGP home pages for information.

The O. volvulus EST program was carried out by Steve Williams (MA, USA).

Loa loa

The preliminary analysis of the dataset is available here

L. loa is a cutaneous parasite of humans in Africa, caiusing significant morbidity. See the FGP home pages for information.

A pilot project has been carried out in collaboration with Amy Klion (USA)

Litomosoides sigmodontis

The preliminary analysis of the dataset is available here

L. sigmodontis is a filarial parasite of rodents used as a model for human infection.

The L. sigmodontis EST project was carried out in Edinburgh in collaboration with Judi Allen.

Dirofilaria immitis

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