The Filarial Genome Project
The Filarial Genome Project
* identify new drug targets in human parasitic filarial nematodes through EST sequencing
* identify new vaccine candidates in human parasitic filarial nematodes through EST sequencing
* map and sequence the genome of the filariasis nematode Brugia malayi
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* Filarial Biology and Pathology * The Filarial Genome Project * |
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* Brugia EST sequencing * Other filarial ESTs * * Brugia malayi Genome Sequencing at TIGR * * Brugia malayi genome sequence from Edinburgh/Sanger Institute * * Wolbachia genome sequencing of Brugia and Onchocerca * |
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The FGP www site including summaries of findings, methods, resources and contacts |
Mark Blaxter |
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An introduction to the biology of filaria and the diseases they cause |
Mark Blaxter |
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The NEMBASE database includes EST information on several filarial nematodes. NEMBASE is a postgreSQL based database for the display and analysis of "fragmented" or "partial" genome sequence, such as that produced in EST or GSS projects |
Mark Blaxter |
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We host the FUNK gene nomenclature database for B. malayi |
Mark Blaxter |
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Using gridded BAC libraries, we are generating genome maps for Brugia malayi |
Mark Blaxter |
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TIGR has been funded by the US NIAID to perform an eight-fold coverage shotgun sequence survey of the Brugia malayi genome. |
For B. malayi Comments/Questions send mail to bmalayi@tigr.org |
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In collaboration with the Sanger Institute we are generating GSS data for B. malayi |
Claire Whitton and Mark Blaxter |
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Brugia malayi genome sequence from Edinburgh and the Sanger Institute |
In collaboration with the Sanger Institute we are sequncing selected B. malayi BAC clones that cover genes-of-interest. |
Mark Blaxter |
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The Brugia malayi mitochondrial genome |
We have sequenced the 13 kb mitochondrial genome of B. malayi |
Mark Blaxter |
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The Wolbachia endosymbionts of Brugia malayi and Onchocerca volvulus |
Filarial nematodes live in symbiosis with a bacterial partner, closely related to the Wolbachia parasites of arthropods. We are in collaboration with the Sanger Institute, NEB and TIGR, sequencing and analysing the genomes of two nematode symbionts |
Katelyn Fenn and Mark Blaxter |
